Anxiety and depression in children and adults: influence of serotonergic and neurotrophic genes?

There are two major hypotheses regarding the etiology of anxiety and depression: the mono-amine hypothesis and the hypothesis of an abnormal stress response acting partly via reduced neurogenesis. Association studies have focused on genes involved in these processes, but with inconclusive results. This study investigated the effect of 45 single nucleotide polymorphisms (SNPs) in genes encoding for serotonin receptors 1A, 1D, 2A, catechol-O-methyltransferase (COMT), tryptophane hydroxylase type 2 (TPH2), brain derived neurotrophic factor (BDNF), PlexinA2 and regulators of G-protein-coupled sign... Mehr ...

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Verfasser: Middeldorp, C.M.
Slof-Op 't Landt, M.C.T.
Medland, S.E.
van Beijsterveldt, C.E.M.
Bartels, M.
Willemsen, G.
Hottenga, J.J.
de Geus, E.J.C.
Suchiman, H.E.D.
Dolan, C.V.
Neale, M.C.
Slagboom, P.E.
Boomsma, D.I.
Dokumenttyp: Artikel
Erscheinungsdatum: 2010
Reihe/Periodikum: Middeldorp , C M , Slof-Op 't Landt , M C T , Medland , S E , van Beijsterveldt , C E M , Bartels , M , Willemsen , G , Hottenga , J J , de Geus , E J C , Suchiman , H E D , Dolan , C V , Neale , M C , Slagboom , P E & Boomsma , D I 2010 , ' Anxiety and depression in children and adults: influence of serotonergic and neurotrophic genes? ' , Genes, Brain and Behavior , vol. 9 , no. 6 , pp. 808-816 . https://doi.org/10.1111/j.1601-183X.2010.00619.x
Schlagwörter: /dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_ / name=Netherlands Twin Register (NTR)
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-26843704
Datenquelle: BASE; Originalkatalog
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Link(s) : https://research.vu.nl/en/publications/3a48ad1a-b85c-4a1d-8241-5d0c5e9b4fd3