We assessed gene expression profiles in 2,752 twins, using a classic twin design to quantify expression heritability and quantitative trait loci (eQTLs) in peripheral blood. The most highly heritable genes (â ̂1/4777) were grouped into distinct expression clusters, enriched in gene-poor regions, associated with specific gene function or ontology classes, and strongly associated with disease designation. The design enabled a comparison of twin-based heritability to estimates based on dizygotic identity-by-descent sharing and distant genetic relatedness. Consideration of sampling variation sugge... Mehr ...
| Verfasser: |
Wright, F.A.
Sullivan, P.F.
Brooks, A.I.
Zou, F.
Sun, W.
Xia, K.
Madar, V.
Jansen, R.
Chung, W.
Zhou, Y.H.
Abdellaoui, A.
Batista, S.
Butler, C.
Chen, G.
Chen, T.H.
D’Ambrosio, D.
Gallins, P.
Ha, M.J.
Hottenga, J.J.
Huang, S.
Kattenberg, V.M.
Kochar, J.
Middeldorp, C.M.
Qu, A.
Shabalin, A.
Tischfield, J.
Todd, L.
Tzeng, J.Y.
Grootheest, G.
Vink, J.M.
Wang, Q.
Wang, W.
Willemsen, G.
Smit, J.H.
de Geus, E.J.C.
Yin, Z.
Penninx, B.W.J.H.
Boomsma, D.I. |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2014 |
| Reihe/Periodikum: |
Wright , F A , Sullivan , P F , Brooks , A I , Zou , F , Sun , W , Xia , K , Madar , V , Jansen , R , Chung , W , Zhou , Y H , Abdellaoui , A , Batista , S , Butler , C , Chen , G , Chen , T H , D’Ambrosio , D , Gallins , P , Ha , M J , Hottenga , J J , Huang , S , Kattenberg , V M , Kochar , J , Middeldorp , C M , Qu , A , Shabalin , A , Tischfield , J , Todd , L , Tzeng , J Y , Grootheest , G , Vink , J M , Wang , Q , Wang , W , Willemsen , G , Smit , J H , de Geus , E J C , Yin , Z , Penninx , B W J H & Boomsma , D I 2014 , ' Heritability and genomics of gene expression in peripheral blood ' , Nature Genetics , vol. 46 , no. 5 , pp. 430-437 . https://doi.org/10.1038/ng.2951 |
| Schlagwörter: |
/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR)
/ /dk/atira/pure/sustainabledevelopmentgoals/no_poverty
/ name=SDG 1 - No Poverty |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-26843646 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
|
https://research.vu.nl/en/publications/3344f72d-38e0-45a2-8fb4-3fd581ad8254 |
