Association of maternal prenatal smoking GFI1-locus and cardio-metabolic phenotypes in 18,212 adults
BACKGROUND: DNA methylation at the GFI1-locus has been repeatedly associated with exposure to smoking from the foetal period onwards. We explored whether DNA methylation may be a mechanism that links exposure to maternal prenatal smoking with offspring's adult cardio-metabolic health. METHODS: We meta-analysed the association between DNA methylation at GFI1-locus with maternal prenatal smoking, adult own smoking, and cardio-metabolic phenotypes in 22 population-based studies from Europe, Australia, and USA (n = 18,212). DNA methylation at the GFI1-locus was measured in whole-blood. Multivariab... Mehr ...
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2018 |
Reihe/Periodikum: | Boomsma , D I , for the BIOS Consortium & for the GLOBAL Meth QTL Consortium 2018 , ' Association of maternal prenatal smoking GFI1-locus and cardio-metabolic phenotypes in 18,212 adults ' , Ebiomedicine , vol. 38 , pp. 206-216 . https://doi.org/10.1016/j.ebiom.2018.10.066 |
Schlagwörter: | /dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_ / name=Netherlands Twin Register (NTR) / /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being / name=SDG 3 - Good Health and Well-being |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-26843292 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | https://research.vu.nl/en/publications/1715defe-b26c-4b97-b30f-d6f2051d52bc |