Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes:findings from the ENIGMA Epigenetics Working Group
DNA methylation, which is modulated by both genetic factors and environmental exposures, may offer a unique opportunity to discover novel biomarkers of disease-related brain phenotypes, even when measured in other tissues than brain, such as blood. A few studies of small sample sizes have revealed associations between blood DNA methylation and neuropsychopathology, however, large-scale epigenome-wide association studies (EWAS) are needed to investigate the utility of DNA methylation profiling as a peripheral marker for the brain. Here, in an analysis of eleven international cohorts, totalling... Mehr ...
Verfasser: |
Jia, Tianye
van Dongen, Jenny
Armstrong, Nicola J
den Braber, Anouk
Jansen, Rick
Brouwer, Rachel
Boomsma, Dorret I
van t Ent, Dennis
Desrivières, Sylvane |
Dokumenttyp: |
Artikel |
Erscheinungsdatum: |
2021 |
Reihe/Periodikum: |
Jia , T , van Dongen , J , Armstrong , N J , den Braber , A , Jansen , R , Brouwer , R , Boomsma , D I , van t Ent , D , Desrivières , S & ENIGMA Epigenetics Working Group 2021 , ' Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes : findings from the ENIGMA Epigenetics Working Group ' , Molecular Psychiatry , vol. 26 , no. 8 , pp. 3884-3895 . https://doi.org/10.1038/s41380-019-0605-z |
Schlagwörter: |
/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR)
/ /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
/ name=SDG 3 - Good Health and Well-being |
Sprache: |
Englisch |
Permalink: |
https://search.fid-benelux.de/Record/base-26843263 |
Datenquelle: |
BASE;
Originalkatalog |
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Link(s) :
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https://research.vu.nl/en/publications/13d1ee9c-a0f7-49d9-a81a-e9b7c697fe06 |