Imaging genetic analyses use heritability calculations to measure the fraction of phenotypic variance attributable to additive genetic factors. We tested the agreement between heritability estimates provided by four methods that are used for heritability estimates in neuroimaging traits. SOLAR-Eclipse and OpenMx use iterative maximum likelihood estimation (MLE) methods. Accelerated Permutation inference for ACE (APACE) and fast permutation heritability inference (FPHI), employ fast, non-iterative approximation-based methods. We performed this evaluation in a simulated twin-sibling pedigree and... Mehr ...
Verfasser: |
Kochunov, Peter
Patel, Binish
Ganjgahi, Habib
Donohue, Brian
Ryan, Meghann
Hong, Elliot L.
Chen, Xu
Adhikari, Bhim
Jahanshad, Neda
Thompson, Paul M.
Van’t Ent, Dennis
den Braber, Anouk
de Geus, Eco J.C.
Brouwer, Rachel M.
Boomsma, Dorret I.
Hulshoff Pol, Hilleke E.
de Zubicaray, Greig I.
McMahon, Katie L.
Martin, Nicholas G.
Wright, Margaret J.
Nichols, Thomas E. |
Dokumenttyp: |
Artikel |
Erscheinungsdatum: |
2019 |
Reihe/Periodikum: |
Kochunov , P , Patel , B , Ganjgahi , H , Donohue , B , Ryan , M , Hong , E L , Chen , X , Adhikari , B , Jahanshad , N , Thompson , P M , Van’t Ent , D , den Braber , A , de Geus , E J C , Brouwer , R M , Boomsma , D I , Hulshoff Pol , H E , de Zubicaray , G I , McMahon , K L , Martin , N G , Wright , M J & Nichols , T E 2019 , ' Homogenizing estimates of heritability among SOLAR-eclipse, OpenMX, APACE, and FPHI software packages in neuroimaging data ' , Frontiers in Neuroinformatics , vol. 13 , no. March , 16 , pp. 1-11 . https://doi.org/10.3389/fninf.2019.00016 |
Schlagwörter: |
Computational methods
/ DTI
/ Genetics
/ Heritability
/ Imaging genetics
/ Population
/ Reproducability
/ /dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR) |
Sprache: |
Englisch |
Permalink: |
https://search.fid-benelux.de/Record/base-26843088 |
Datenquelle: |
BASE;
Originalkatalog |
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BASE |
Link(s) :
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https://research.vu.nl/en/publications/00d5d7ad-4517-40ac-a2ab-4327ce5f847d |