Critical evaluation of the newborn screening for congenital hypothyroidism in the Netherlands
Objective: Congenital hypothyroidism (CH) is defined as thyroid hormone deficiency at birth due to disorders of the thyroid gland (thyroidal CH, CH-T), or the hypothalamus or pituitary (central CH, CH-C). The Dutch Newborn Screening (NBS) strategy is primarily based on determination of thyroxine (T4) concentrations in dried blood spots followed, if necessary, by thyroid-stimulating hormone (TSH) and thyroxine-binding globulin (TBG) measurement enabling detection of both CH-T and CH-C. A calculated T4/TBG ratio serves as an indirect measure for free T4. A T4/TBG ratio ≤ 17 in a second heel punc... Mehr ...
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2020 |
Reihe/Periodikum: | European Journal of Endocrinology ; volume 183, issue 3, page 265-273 ; ISSN 0804-4643 1479-683X |
Verlag/Hrsg.: |
Oxford University Press (OUP)
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Schlagwörter: | Endocrinology / General Medicine / Diabetes and Metabolism |
Sprache: | unknown |
Permalink: | https://search.fid-benelux.de/Record/base-26842342 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | http://dx.doi.org/10.1530/eje-19-1048 |