Economic evaluation of a pharmacogenetic dosing algorithm for coumarin anticoagulants in The Netherlands
AIM: To investigate the cost-effectiveness of a pharmacogenetic dosing algorithm versus a clinical dosing algorithm for coumarin anticoagulants in The Netherlands. MATERIALS & METHODS: A decision-analytic Markov model was used to analyze the cost-effectiveness of pharmacogenetic dosing of phenprocoumon and acenocoumarol versus clinical dosing. RESULTS: Pharmacogenetic dosing increased costs by €33 and quality-adjusted life-years (QALYs) by 0.001. The incremental cost-effectiveness ratios were €28,349 and €24,427 per QALY gained for phenprocoumon and acenocoumarol, respectively. At a willin... Mehr ...
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2015 |
Schlagwörter: | Acenocoumarol / Aged / 80 and over / Algorithms / Anticoagulants / Cost-Benefit Analysis / Coumarins / Drug Costs / Humans / Markov Chains / Middle Aged / Netherlands / Pharmacogenetics / Phenprocoumon / Quality-Adjusted Life Years / Thromboembolism / Taverne |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-26836935 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | https://dspace.library.uu.nl/handle/1874/428612 |