Atopy and new-onset asthma in young Danish farmers in the Netherlands and CD14, TLR2, and TLR4 genetic polymorphisms: a nested case‐control study

Background Evidence exists that exposure to high levels of microbial agents such as endotoxin in the farm environment decreases the risk of atopic sensitization. Genetic variation in innate immunity genes may modulate the response to microbial agents and thus influence susceptibility to asthma and atopy. Objective To study potential associations between single nucleotide polymorphisms (SNPs) in CD14, Toll‐like receptor 2 (TLR2), and TLR4 genes, and atopy and new‐onset asthma in young farmers. Methods A nested case–control study was conducted within a cohort of 1901 young Danish farmers. We gen... Mehr ...