Breast cancer risk in female survivors of Hodgkin's lymphoma: lower risk after smaller radiation volumes
PURPOSE: We assessed the long-term risk of breast cancer (BC) after treatment for Hodgkin's lymphoma (HL). We focused on the volume of breast tissue exposed to radiation and the influence of gonadotoxic chemotherapy (CT). PATIENTS AND METHODS: We performed a cohort study among 1,122 female 5-year survivors treated for HL before the age of 51 years between 1965 and 1995. We compared the incidence of BC with that in the general population. To assess the risk according to radiation volume and hormone factors, we performed multivariate Cox regression analyses. RESULTS: After a median follow-up of... Mehr ...
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2009 |
Schlagwörter: | Adult / Breast Neoplasms / Dose-Response Relationship / Radiation / Female / Follow-Up Studies / Hodgkin Disease / Humans / Incidence / Middle Aged / Multivariate Analysis / Neoplasms / Second Primary / Netherlands / Outcome Assessment (Health Care) / Proportional Hazards Models / Radiotherapy / Radiotherapy Dosage / Risk Factors / Survival Analysis / Survivors / Young Adult |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-26835932 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | https://dspace.library.uu.nl/handle/1874/380461 |