Meta-analysis of the Genome Wide Association Studies (GWAS) on the intolerance of Angiotensin Converting Enzyme Inhibitors (ACEIs)

Background: ACEIs are frequently used to treat hypertension and heart failure. Cough and angioedema are the two main adverse drug reactions (ADRs) associated with ACEI use that occur in up to 20% of the patients and are the main reason of therapy discontinuation. Objectives: To identify single nucleotide polymorphisms (SNPs) associated with switching of an ACEI to an angiotensin receptor blocker (ARB) as a marker for ADRs. Methods: A cohort of patients starting ACEIs was identified within the Rotterdam Study in the Netherlands and the GoDARTS study in Scotland. Cases were subjects that switche... Mehr ...