Upfront Genotyping of DPYD*2A to Individualize Fluoropyrimidine Therapy: A Safety and Cost Analysis
PURPOSE: Fluoropyrimidines are frequently prescribed anticancer drugs. A polymorphism in the fluoropyrimidine metabolizing enzyme dihydropyrimidine dehydrogenase (DPD; ie, DPYD*2A) is strongly associated with fluoropyrimidine-induced severe and life-threatening toxicity. This study determined the feasibility, safety, and cost of DPYD*2A genotype-guided dosing. PATIENTS AND METHODS: Patients intended to be treated with fluoropyrimidine-based chemotherapy were prospectively genotyped for DPYD*2A before start of therapy. Variant allele carriers received an initial dose reduction of ≥ 50% followed... Mehr ...
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2016 |
Schlagwörter: | Adult / Aged / 80 and over / Alleles / Antineoplastic Combined Chemotherapy Protocols / Colorectal Neoplasms / Costs and Cost Analysis / Dihydrouracil Dehydrogenase (NADP) / Female / Genetic Testing / Genotyping Techniques / Humans / Male / Middle Aged / Netherlands / Precision Medicine / Prospective Studies / Pyrimidines / Young Adult / Clinical Trial / Multicenter Study / Research Support / Non-U.S. Gov't |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-26835327 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | https://dspace.library.uu.nl/handle/1874/345672 |