Risk of hip fractures associated with benzodiazepines: Applying common protocol to a multi-database nested case-control study. The protect project

Background: The association between benzodiazepines (BZD) and hip fractures has been estimated in several observational studies although diverse methodologies and definitions have hampered comparability. Objectives: To evaluate the discrepancies in the risk estimates of hip/femur fractures associated with BDZs across different databases and to assess the impact of different matching strategies. Methods: A case control study nested in a cohort of BZD users, examining their association with the risk of hip/ femur fracture between 2001 and 2009, was performed within 3 databases, the BIFAP (Spain)... Mehr ...