Use of Β-Blockers and the Risk of Hip/Femur Fracture in the United Kingdom and The Netherlands

Data from in vivo studies have indicated a role for Β-blockers in the prevention of bone loss. Some epidemiological studies have found protective effects of b-blockers on fracture risk. However, there is limited information on the association with cumulative dose and type of Β-blockers used. We conducted two casecontrol studies using data from the UK General Practice Research Database (GPRD) and the Dutch PHARMO Record Linkage System (RLS). Cases were patients with a first hip or femur fracture; controls were individually matched on practice/region, gender, year of birth, and calendar time. Cu... Mehr ...