Economic evaluation of tramadol/paracetamol combination tablets for osteoarthritis pain in the Netherlands

Objective: To compare the costs of treating osteoarthritis (OA) pain using combination tramadol/paracetamol tablets, NSAIDs alone, NSAIDs plus proton pump inhibitors (PPIs), or NSAIDs plus histamine H2-receptor antagonists (H2RAs) from the perspective of the Dutch healthcare system. Design and methods: A decision-analytical model was constructed to model the cost outcomes of the four treatment strategies over 6 months. A cost-minimisation approach was used, which considered data related to resource utilisation, medication costs and costs for the treatment of adverse events. Data, derived mainl... Mehr ...