Voriconazole metabolism is influenced by severe inflammation:a prospective study
BACKGROUND: During an infection or inflammation, several drug-metabolizing enzymes in the liver are down-regulated, including cytochrome P450 iso-enzymes. Since voriconazole is extensively metabolized by cytochrome P450 iso-enzymes, the metabolism of voriconazole can be influenced during inflammation via reduced clearance of the drug, resulting in higher voriconazole trough concentrations. OBJECTIVE: To investigate prospectively the influence of inflammation on voriconazole metabolism and voriconazole trough concentrations. METHODS: A prospective observational study was performed at the Univer... Mehr ...
| Verfasser: |
Veringa, A.
ter Avest, M.
Span, L.F.R.
van den Heuvel, E.R.
Touw, D.J.
Zijlstra, J.G.
Kosterink, J.G.W.
van der Werf, T.S.
Alffenaar, J.W.C. |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2017 |
| Reihe/Periodikum: |
Veringa , A , ter Avest , M , Span , L F R , van den Heuvel , E R , Touw , D J , Zijlstra , J G , Kosterink , J G W , van der Werf , T S & Alffenaar , J W C 2017 , ' Voriconazole metabolism is influenced by severe inflammation : a prospective study ' , Journal of Antimicrobial Chemotherapy , vol. 72 , no. 1 , pp. 261-267 . https://doi.org/10.1093/jac/dkw349 |
| Schlagwörter: |
Academic Medical Centers
/ Adult
/ Aged
/ Antifungal Agents/metabolism
/ Biotransformation
/ Blood Chemical Analysis
/ C-Reactive Protein/analysis
/ Female
/ Humans
/ Inflammation/pathology
/ Male
/ Middle Aged
/ Netherlands
/ Prospective Studies
/ Voriconazole/metabolism
/ /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
/ name=SDG 3 - Good Health and Well-being |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-26828996 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
|
https://research.tue.nl/en/publications/2bff6c8d-7107-4c53-b487-072ee08392a7 |
