Antenatal allopurinol for reduction of birth asphyxia induced brain damage (ALLO-Trial); a randomized double blind placebo controlled multicenter study
BACKGROUND Hypoxic-ischaemic encephalopathy is associated with development of cerebral palsy and cognitive disability later in life and is therefore one of the fundamental problems in perinatal medicine. The xanthine-oxidase inhibitor allopurinol reduces the formation of free radicals, thereby limiting the amount of hypoxia-reperfusion damage. In case of suspected intra-uterine hypoxia, both animal and human studies suggest that maternal administration of allopurinol immediately prior to delivery reduces hypoxic-ischaemic encephalopathy. METHODS/DESIGN The proposed trial is a randomized double... Mehr ...
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Dokumenttyp: | Journal article |
Erscheinungsdatum: | 2010 |
Verlag/Hrsg.: |
BioMed Central Ltd.
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Schlagwörter: | Humans / Hypoxia-Ischemia / Brain / Asphyxia Neonatorum / Allopurinol / Phosphopyruvate Hydratase / Xanthine Oxidase / Nerve Growth Factors / S100 Proteins / Free Radical Scavengers / Prenatal Care / Multivariate Analysis / Regression Analysis / Prospective Studies / Pilot Projects / Double-Blind Method / Pregnancy / Infant / Newborn / Netherlands / Female / Fetal Hypoxia / S100 Calcium Binding Protein beta Subunit / Biomarkers |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-26827855 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | http://hdl.handle.net/2440/88489 |