In the Dutch CAPRI registry, cabazitaxel treatment as the standard of care and in trials was analyzed. Patients treated with cabazitaxel in trials were fitter and showed outcomes comparable to registration trials. Conversely, those treated in daily practice showed features of more aggressive disease and worse outcome. This may be explained by a worse prognosis at cabazitaxel initiation. Background: Cabazitaxel has been shown to improve overall survival (OS) in metastatic castration-resistant prostate cancer (mCRPC) patients after docetaxel in the TROPIC trial. However, trial populations may no... Mehr ...
| Verfasser: |
Westgeest, Hans M.
Kuppen, Malou C. P.
van den Eertwegh, Alphonsus J. M.
de Wit, Ronald
Coenen, Juleon L. L. M.
van den Berg, H. P. (Pieter)
Mehra, Niven
van Oort, Inge M.
Fossion, Laurent M. C. L.
Hendriks, Mathijs P.
Bloemendal, Haiko J.
van de Luijtgaarden, Addy C. M.
Huinink, Daan ten Bokkel
van den Bergh, A. C. M. (Fons)
van den Bosch, Joan
Polee, Marco B.
Weijl, Nir
Bergman, Andre M.
Uyl-de Groot, Carin A.
Gerritsen, Winald R. |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2019 |
| Reihe/Periodikum: |
Westgeest , H M , Kuppen , M C P , van den Eertwegh , A J M , de Wit , R , Coenen , J L L M , van den Berg , H P , Mehra , N , van Oort , I M , Fossion , L M C L , Hendriks , M P , Bloemendal , H J , van de Luijtgaarden , A C M , Huinink , D T B , van den Bergh , A C M , van den Bosch , J , Polee , M B , Weijl , N , Bergman , A M , Uyl-de Groot , C A & Gerritsen , W R 2019 , ' Second-Line Cabazitaxel Treatment in Castration-Resistant Prostate Cancer Clinical Trials Compared to Standard of Care in CAPRI : Observational Study in the Netherlands ' , Clinical genitourinary cancer , vol. 17 , no. 5 , pp. E946-E956 . https://doi.org/10.1016/j.clgc.2019.05.018 |
| Schlagwörter: |
Postdocetaxel
/ Real-world outcomes
/ Registry
/ Trial eligibility
/ Trial population
/ OPEN-LABEL
/ ABIRATERONE ACETATE
/ INCREASED SURVIVAL
/ PLUS PREDNISONE
/ DOCETAXEL
/ MEN
/ CHEMOTHERAPY
/ CYCLES
/ SAFETY |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-26827060 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
|
https://hdl.handle.net/11370/f99c5aaf-9c74-4512-838b-f4ed61f11443 |
