Real-world Outcomes of Ipilimumab Plus Nivolumab Combination Therapy in a Nation-wide Cohort of Advanced Melanoma Patients in the Netherlands

In phase III trials, ipilimumab plus nivolumab combination therapy is highly efficacious for advanced melanoma, despite many treatment-related grades 3-4 adverse events. Here, we report real-world safety and survival outcomes of ipilimumab plus nivolumab for advanced melanoma. Patients with advanced melanoma who received first-line ipilimumab plus nivolumab between January 1, 2015 and June 30, 2021 were selected from the Dutch Melanoma Treatment Registry. We evaluated response status at 3, 6, 12, 18, and 24 months. OS and PFS were estimated with the Kaplan-Meier method. Separate analyses were... Mehr ...

Verfasser: van Zeijl, Michiel C T
van Breeschoten, Jesper
de Wreede, Liesbeth C
Wouters, Michel W J M
Hilarius, Doranne L
Blank, Christian U
Aarts, Maureen J B
van den Berkmortel, Franchette W P J
de Groot, Jan Willem B
Hospers, Geke A P
Kapiteijn, Ellen
Piersma, Djura
van Rijn, Rozemarijn S
Stevense-den Boer, Marion A
van der Veldt, Astrid A M
Vreugdenhil, Gerard
Boers-Sonderen, Marye J
Suijkerbuijk, Karijn P M
Haanen, John B A G
van den Eertwegh, Alfons J M
Dokumenttyp: Artikel
Erscheinungsdatum: 2023
Reihe/Periodikum: van Zeijl , M C T , van Breeschoten , J , de Wreede , L C , Wouters , M W J M , Hilarius , D L , Blank , C U , Aarts , M J B , van den Berkmortel , F W P J , de Groot , J W B , Hospers , G A P , Kapiteijn , E , Piersma , D , van Rijn , R S , Stevense-den Boer , M A , van der Veldt , A A M , Vreugdenhil , G , Boers-Sonderen , M J , Suijkerbuijk , K P M , Haanen , J B A G & van den Eertwegh , A J M 2023 , ' Real-world Outcomes of Ipilimumab Plus Nivolumab Combination Therapy in a Nation-wide Cohort of Advanced Melanoma Patients in the Netherlands ' , Journal of Immunotherapy , vol. 46 , no. 5 , pp. 197-204 . https://doi.org/10.1097/CJI.0000000000000468
Schlagwörter: Humans / Antineoplastic Combined Chemotherapy Protocols/adverse effects / Brain Neoplasms/drug therapy / Ipilimumab/therapeutic use / Melanoma/pathology / Netherlands / Nivolumab/therapeutic use
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-26826976
Datenquelle: BASE; Originalkatalog
Powered By: BASE
Link(s) : https://hdl.handle.net/11370/efed156f-7b5b-414a-a016-bf59943ddcb8