Antiviral-resistant cytomegalovirus infections in solid organ transplantation in the Netherlands
Objectives: Antiviral resistance in cytomegalovirus (CMV) may result from mutations in the molecular targets of antiviral agents. The aim of this study was to investigate both the prevalence of resistance-associated mutations and the factors associated with antiviral resistance in solid organ transplant (SOT) patients with repeated high CMV loads during antiviral treatment. Methods: SOT patients were selected retrospectively, based on CMV loads of >30000 IU/mL at least twice in a period during which treatment was given. Patient samples were tested for antiviral resistance by Sanger sequenci... Mehr ...
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| Dokumenttyp: | Artikel |
| Erscheinungsdatum: | 2019 |
| Reihe/Periodikum: | Buter , C C V L , de Voogd , D W K , Blokzijl , H , de Joode , A A E , Berger , S P , Verschuuren , E A M & Niesters , H G M 2019 , ' Antiviral-resistant cytomegalovirus infections in solid organ transplantation in the Netherlands ' , Journal of Antimicrobial Chemotherapy , vol. 74 , no. 8 , pp. 2370-2376 . https://doi.org/10.1093/jac/dkz196 |
| Schlagwörter: | DRUG-RESISTANCE / RISK-FACTORS / MUTATIONS / RECIPIENTS / UL97 / VALGANCICLOVIR / EMERGENCE / OUTCOMES / DISEASE / KINASE |
| Sprache: | Englisch |
| Permalink: | https://search.fid-benelux.de/Record/base-26826753 |
| Datenquelle: | BASE; Originalkatalog |
| Powered By: | BASE |
| Link(s) : | https://hdl.handle.net/11370/e41485bf-0ddd-48a7-a5f3-96164d26b44a |
