Population-specific genotype imputations using minimac or IMPUTE2
In order to meaningfully analyze common and rare genetic variants, results from genome-wide association studies (GWASASs) of multiple cohorts need to be combined in a meta-analysis in order to obtain enough power. This requires all cohorts to have the same single-nucleotide polymorphisms (SNPSNPSNPs) in their GWASASs. To this end, genotypes that have not been measured in a given cohort can be imputed on the basis of a set of reference haplotypes. This protocol provides guidelines for performing imputations with two widely used tools: minimac and IMPUTEPUTEPUTEPUTE2. These guidelines were devel... Mehr ...
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2015 |
Reihe/Periodikum: | van Leeuwen , E M , Kanterakis , A , Deelen , P , Kattenberg , M V , Slagboom , P E , de Bakker , P I W , Wijmenga , C , Swertz , M A , Boomsma , D I , van Duijn , C M , Karssen , L C , Hottenga , J J & Genome Netherlands Consortium 2015 , ' Population-specific genotype imputations using minimac or IMPUTE2 ' , Nature protocols , vol. 10 , no. 9 , pp. 1285-1296 . https://doi.org/10.1038/nprot.2015.077 |
Schlagwörter: | GENOME-WIDE ASSOCIATION / GENETIC-VARIATION / QUALITY-CONTROL / LOW-FREQUENCY / NETHERLANDS / VARIANTS / SEQUENCE / FORMAT / COMMON / SETS |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-26826386 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | https://hdl.handle.net/11370/bfdc749f-207d-4d53-bf86-32fcf8a97185 |