Immunogenicity of bivalent omicron (BA.1) booster vaccination after different priming regimens in health-care workers in the Netherlands (SWITCH ON):results from the direct boost group of an open-label, multicentre, randomised controlled trial

BACKGROUND: Bivalent mRNA-based COVID-19 vaccines encoding the ancestral and omicron spike (S) protein were developed as a countermeasure against antigenically distinct SARS-CoV-2 variants. We aimed to assess the (variant-specific) immunogenicity and reactogenicity of mRNA-based bivalent omicron (BA.1) vaccines in individuals who were primed with adenovirus-based or mRNA-based vaccines encoding the ancestral spike protein. METHODS: We analysed results of the direct boost group of the SWITCH ON study, an open-label, multicentre, randomised controlled trial. Health-care workers from four academi... Mehr ...

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Verfasser: Tan, Ngoc H
Geers, Daryl
Sablerolles, Roos S G
Rietdijk, Wim J R
Goorhuis, Abraham
Postma, Douwe F
Visser, Leo G
Bogers, Susanne
van Dijk, Laura L A
Gommers, Lennert
van Leeuwen, Leanne P M
Boerma, Annemarie
Nijhof, Sander H
van Dort, Karel A
Koopmans, Marion P G
Dalm, Virgil A S H
Lafeber, Melvin
Kootstra, Neeltje A
Huckriede, Anke L W
van Baarle, Debbie
Zaeck, Luca M
GeurtsvanKessel, Corine H
de Vries, Rory D
van der Kuy, P Hugo M
Dokumenttyp: Artikel
Erscheinungsdatum: 2023
Reihe/Periodikum: SWITCH ON Research Group , Tan , N H , Geers , D , Sablerolles , R S G , Rietdijk , W J R , Goorhuis , A , Postma , D F , Visser , L G , Bogers , S , van Dijk , L L A , Gommers , L , van Leeuwen , L P M , Boerma , A , Nijhof , S H , van Dort , K A , Koopmans , M P G , Dalm , V A S H , Lafeber , M , Kootstra , N A , Huckriede , A L W , van Baarle , D , Zaeck , L M , GeurtsvanKessel , C H , de Vries , R D & van der Kuy , P H M 2023 , ' Immunogenicity of bivalent omicron (BA.1) booster vaccination after different priming regimens in health-care workers in the Netherlands (SWITCH ON) : results from the direct boost group of an open-label, multicentre, randomised controlled trial ' , Lancet Infectious Diseases , vol. 23 , no. 8 , pp. 901-913 . https://doi.org/10.1016/S1473-3099(23)00140-8
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-26826142
Datenquelle: BASE; Originalkatalog
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Link(s) : https://hdl.handle.net/11370/a8e22d3d-ad25-42f1-93ea-baf1f04d9649