An economic assessment of losartan-based versus atenolol-based therapy in patients with hypertension and left-ventricular hypertrophy:Results from the Losartan Intervention For Endpoint reduction (LIFE) study adapted to The Netherlands

Background: The Losartan Intervention For Endpoint reduction (LIFE) study was a randomized, doubleblind trial that compared the effects of losartan-based treatment with those of atenolol-based treatment on cardiovascular disease (CVD)-related morbidity and mortality in 9193 patients with hypertension and left-ventricular hypertrophy (LVH). Compared with atenolol, losartan reduced the combined risk for CVD-related morbidity and mortality by 13% (P = 0.021), and reduced the risk for stroke by 25% (P = 0.001), with comparable blood pressure control in both trial arms. Objective: The aim of this s... Mehr ...