The Dutch CAR-T Tumorboard Experience:Population-Based Real-World Data on Patients with Relapsed or Refractory Large B-Cell Lymphoma Referred for CD19-Directed CAR T-Cell Therapy in The Netherlands

The real-world results of chimeric antigen receptor T-cell (CAR-T) therapy for patients with relapsed/refractory (R/R) large B-cell lymphoma (LBCL) substantially differ across countries. In the Netherlands, the CAR-T tumorboard facilitates a unique nationwide infrastructure for referral, eligibility assessment and data collection. The aim of this study was to evaluate real-world outcomes of axicabtagene ciloleucel (axi-cel) in the Dutch population, including the thus-far underreported effects on health-related quality of life (HR-QoL). All patients with R/R LBCL after ≥2 lines of systemic ther... Mehr ...

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Verfasser: Spanjaart, Anne M.
Pennings, Elise R.A.
Mutsaers, Pim G.N.J.
van Dorp, Suzanne
Jak, Margot
van Doesum, Jaap A.
de Boer, Janneke W.
Niezink, Anne G.H.
Kos, Milan
Vermaat, Joost S.P.
Sijs-Szabo, Aniko
van der Poel, Marjolein W.M.
Nijhof, Inger S.
Kuipers, Maria T.
Chamuleau, Martine E.D.
Lugtenburg, Pieternella J.
Doorduijn, Jeanette K.
Serroukh, Yasmina I.M.
Minnema, Monique C.
van Meerten, Tom
Kersten, Marie José
Dokumenttyp: Artikel
Erscheinungsdatum: 2023
Reihe/Periodikum: on behalf of the Dutch CAR-T Tumorboard Consortium , Spanjaart , A M , Pennings , E R A , Mutsaers , P G N J , van Dorp , S , Jak , M , van Doesum , J A , de Boer , J W , Niezink , A G H , Kos , M , Vermaat , J S P , Sijs-Szabo , A , van der Poel , M W M , Nijhof , I S , Kuipers , M T , Chamuleau , M E D , Lugtenburg , P J , Doorduijn , J K , Serroukh , Y I M , Minnema , M C , van Meerten , T & Kersten , M J 2023 , ' The Dutch CAR-T Tumorboard Experience : Population-Based Real-World Data on Patients with Relapsed or Refractory Large B-Cell Lymphoma Referred for CD19-Directed CAR T-Cell Therapy in The Netherlands ' , Cancers , vol. 15 , no. 17 , 4334 . https://doi.org/10.3390/cancers15174334
Schlagwörter: CAR T-cell therapy / LBCL / outcomes / real-world data
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-26825703
Datenquelle: BASE; Originalkatalog
Powered By: BASE
Link(s) : https://hdl.handle.net/11370/829c9b0c-d036-4dd7-936b-f8e896130021