Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney

Verfasser:	Wain, Louise V Vaez, Ahmad Jansen, Rick Joehanes, Roby van der Most, Peter J Erzurumluoglu, A Mesut O'Reilly, Paul F Cabrera, Claudia P Warren, Helen R Rose, Lynda M Verwoert, Germaine C Hottenga, Jouke-Jan Strawbridge, Rona J Esko, Tonu Arking, Dan E Hwang, Shih-Jen Guo, Xiuqing Kutalik, Zoltan Trompet, Stella Shrine, Nick Teumer, Alexander Ried, Janina S Bis, Joshua C Smith, Albert V Amin, Najaf Nolte, Ilja M Lyytikäinen, Leo-Pekka Mahajan, Anubha Wareham, Nicholas J Hofer, Edith Joshi, Peter K Kristiansson, Kati Traglia, Michela Havulinna, Aki S Goel, Anuj Nalls, Mike A Sõber, Siim Vuckovic, Dragana Luan, Jian'an Del Greco M, Fabiola Ayers, Kristin L Marrugat, Jaume Ruggiero, Daniela Lopez, Lorna M Niiranen, Teemu Enroth, Stefan Jackson, Anne U Nelson, Christopher P Huffman, Jennifer E Zhang, Weihua Marten, Jonathan Gandin, Ilaria Harris, Sarah E Zemunik, Tatijana Lu, Yingchang Evangelou, Evangelos Shah, Nabi de Borst, Martin H Mangino, Massimo Prins, Bram P Campbell, Archie Li-Gao, Ruifang Chauhan, Ganesh Oldmeadow, Christopher Abecasis, Gonçalo Abedi, Maryam Barbieri, Caterina M Barnes, Michael R Batini, Chiara Beilby, John Blake, Tineka Boehnke, Michael Bottinger, Erwin P Braund, Peter S Brown, Morris Brumat, Marco Campbell, Harry Chambers, John C Cocca, Massimiliano Collins, Francis Connell, John Cordell, Heather J Damman, Jeffrey J Davies, Gail de Geus, Eco J de Mutsert, Renée Deelen, Joris Demirkale, Yusuf Doney, Alex S F Dörr, Marcus Farrall, Martin Ferreira, Teresa Frånberg, Mattias Gao, He Giedraitis, Vilmantas Gieger, Christian Giulianini, Franco Gow, Alan J Hamsten, Anders Harris, Tamara B Hofman, Albert Holliday, Elizabeth G Hui, Jennie Jarvelin, Marjo-Riitta Johansson, Åsa Johnson, Andrew D Jousilahti, Pekka Jula, Antti Kähönen, Mika Kathiresan, Sekar Khaw, Kay-Tee Kolcic, Ivana Koskinen, Seppo Langenberg, Claudia Larson, Marty Launer, Lenore J Lehne, Benjamin Liewald, David C M Lin, Li Lind, Lars Mach, François Mamasoula, Chrysovalanto Menni, Cristina Mifsud, Borbala Milaneschi, Yuri Morgan, Anna Morris, Andrew D Morrison, Alanna C Munson, Peter J Nandakumar, Priyanka Nguyen, Quang Tri Nutile, Teresa Oldehinkel, Albertine J Oostra, Ben A Org, Elin Padmanabhan, Sandosh Palotie, Aarno Paré, Guillaume Pattie, Alison Penninx, Brenda W J H Poulter, Neil Pramstaller, Peter P Raitakari, Olli T Ren, Meixia Rice, Kenneth Ridker, Paul M Riese, Harriëtte Ripatti, Samuli Robino, Antonietta Rotter, Jerome I Rudan, Igor Saba, Yasaman Saint Pierre, Aude Sala, Cinzia F Sarin, Antti-Pekka Schmidt, Reinhold Scott, Rodney Seelen, Marc A Shields, Denis C Siscovick, David Sorice, Rossella Stanton, Alice Stott, David J Sundström, Johan Swertz, Morris Taylor, Kent D Thom, Simon Tzoulaki, Ioanna Tzourio, Christophe Uitterlinden, André G Völker, Uwe Vollenweider, Peter Wild, Sarah Willemsen, Gonneke Wright, Alan F Yao, Jie Thériault, Sébastien Conen, David Attia, John Sever, Peter Debette, Stéphanie Mook-Kanamori, Dennis O Zeggini, Eleftheria Spector, Tim D van der Harst, Pim Palmer, Colin N A Vergnaud, Anne-Claire Loos, Ruth J F Polasek, Ozren Starr, John M Girotto, Giorgia Hayward, Caroline Kooner, Jaspal S Lindgren, Cecila M Vitart, Veronique Samani, Nilesh J Tuomilehto, Jaakko Gyllensten, Ulf Knekt, Paul Deary, Ian J Ciullo, Marina Elosua, Roberto Keavney, Bernard D Hicks, Andrew A Scott, Robert A Gasparini, Paolo Laan, Maris Liu, YongMei Watkins, Hugh Hartman, Catharina A Salomaa, Veikko Toniolo, Daniela Perola, Markus Wilson, James F Schmidt, Helena Zhao, Jing Hua Lehtimäki, Terho van Duijn, Cornelia M Gudnason, Vilmundur Psaty, Bruce M Peters, Annette Rettig, Rainer James, Alan Jukema, J Wouter Strachan, David P Palmas, Walter Metspalu, Andres Ingelsson, Erik Boomsma, Dorret I Franco, Oscar H Bochud, Murielle Newton-Cheh, Christopher Munroe, Patricia B Elliott, Paul Chasman, Daniel I Chakravarti, Aravinda Knight, Joanne Morris, Andrew P Levy, Daniel Tobin, Martin D Snieder, Harold Caulfield, Mark J Ehret, Georg B
Dokumenttyp:	Artikel
Erscheinungsdatum:	2017
Reihe/Periodikum:	Wain , L V , Vaez , A , Jansen , R , Joehanes , R , van der Most , P J , Erzurumluoglu , A M , O'Reilly , P F , Cabrera , C P , Warren , H R , Rose , L M , Verwoert , G C , Hottenga , J-J , Strawbridge , R J , Esko , T , Arking , D E , Hwang , S-J , Guo , X , Kutalik , Z , Trompet , S , Shrine , N , Teumer , A , Ried , J S , Bis , J C , Smith , A V , Amin , N , Nolte , I M , Lyytikäinen , L-P , Mahajan , A , Wareham , N J , Hofer , E , Joshi , P K , Kristiansson , K , Traglia , M , Havulinna , A S , Goel , A , Nalls , M A , Sõber , S , Vuckovic , D , Luan , J , Del Greco M , F , Ayers , K L , Marrugat , J , Ruggiero , D , Lopez , L M , Niiranen , T , Enroth , S , Jackson , A U , Nelson , C P , Huffman , J E , Zhang , W , Marten , J , Gandin , I , Harris , S E , Zemunik , T , Lu , Y , Evangelou , E , Shah , N , de Borst , M H , Mangino , M , Prins , B P , Campbell , A , Li-Gao , R , Chauhan , G , Oldmeadow , C , Abecasis , G , Abedi , M , Barbieri , C M , Barnes , M R , Batini , C , Beilby , J , Blake , T , Boehnke , M , Bottinger , E P , Braund , P S , Brown , M , Brumat , M , Campbell , H , Chambers , J C , Cocca , M , Collins , F , Connell , J , Cordell , H J , Damman , J J , Davies , G , de Geus , E J , de Mutsert , R , Deelen , J , Demirkale , Y , Doney , A S F , Dörr , M , Farrall , M , Ferreira , T , Frånberg , M , Gao , H , Giedraitis , V , Gieger , C , Giulianini , F , Gow , A J , Hamsten , A , Harris , T B , Hofman , A , Holliday , E G , Hui , J , Jarvelin , M-R , Johansson , Å , Johnson , A D , Jousilahti , P , Jula , A , Kähönen , M , Kathiresan , S , Khaw , K-T , Kolcic , I , Koskinen , S , Langenberg , C , Larson , M , Launer , L J , Lehne , B , Liewald , D C M , Lin , L , Lind , L , Mach , F , Mamasoula , C , Menni , C , Mifsud , B , Milaneschi , Y , Morgan , A , Morris , A D , Morrison , A C , Munson , P J , Nandakumar , P , Nguyen , Q T , Nutile , T , Oldehinkel , A J , Oostra , B A , Org , E , Padmanabhan , S , Palotie , A , Paré , G , Pattie , A , Penninx , B W J H , Poulter , N , Pramstaller , P P , Raitakari , O T , Ren , M , Rice , K , Ridker , P M , Riese , H , Ripatti , S , Robino , A , Rotter , J I , Rudan , I , Saba , Y , Saint Pierre , A , Sala , C F , Sarin , A-P , Schmidt , R , Scott , R , Seelen , M A , Shields , D C , Siscovick , D , Sorice , R , Stanton , A , Stott , D J , Sundström , J , Swertz , M , Taylor , K D , Thom , S , Tzoulaki , I , Tzourio , C , Uitterlinden , A G , Völker , U , Vollenweider , P , Wild , S , Willemsen , G , Wright , A F , Yao , J , Thériault , S , Conen , D , Attia , J , Sever , P , Debette , S , Mook-Kanamori , D O , Zeggini , E , Spector , T D , van der Harst , P , Palmer , C N A , Vergnaud , A-C , Loos , R J F , Polasek , O , Starr , J M , Girotto , G , Hayward , C , Kooner , J S , Lindgren , C M , Vitart , V , Samani , N J , Tuomilehto , J , Gyllensten , U , Knekt , P , Deary , I J , Ciullo , M , Elosua , R , Keavney , B D , Hicks , A A , Scott , R A , Gasparini , P , Laan , M , Liu , Y , Watkins , H , Hartman , C A , Salomaa , V , Toniolo , D , Perola , M , Wilson , J F , Schmidt , H , Zhao , J H , Lehtimäki , T , van Duijn , C M , Gudnason , V , Psaty , B M , Peters , A , Rettig , R , James , A , Jukema , J W , Strachan , D P , Palmas , W , Metspalu , A , Ingelsson , E , Boomsma , D I , Franco , O H , Bochud , M , Newton-Cheh , C , Munroe , P B , Elliott , P , Chasman , D I , Chakravarti , A , Knight , J , Morris , A P , Levy , D , Tobin , M D , Snieder , H , Caulfield , M J & Ehret , G B 2017 , ' Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney ' , Hypertension , vol. 70 , no. 3 , pp. E4-+ . https://doi.org/10.1161/HYPERTENSIONAHA.117.09438 ; ISSN:0194-911X
Schlagwörter:	blood pressure / cardiovascular risk / complex traits / eSNP / GWAS / hypertension / PERIPHERAL-BLOOD / COMMON VARIANTS / PULSE PRESSURE / CENTRIC ARRAY / INDIVIDUALS / TRAITS / METAANALYSIS / NETHERLANDS / TARGET
Sprache:	Englisch
Permalink:	https://search.fid-benelux.de/Record/base-26825503
Datenquelle:	BASE; Originalkatalog
Powered By:	BASE
Link(s) :	http://hdl.handle.net/11370/6bc203ce-e3ed-4dec-b0ce-c7ec1cdfbfd8

Elevated blood pressure is a major risk factor for cardiovascular disease and has a substantial genetic contribution. Genetic variation influencing blood pressure has the potential to identify new pharmacological targets for the treatment of hypertension. To discover additional novel blood pressure loci, we used 1000 Genomes Project-based imputation in 150 134 European ancestry individuals and sought significant evidence for independent replication in a further 228 245 individuals. We report 6 new signals of association in or near HSPB7, TNXB, LRP12, LOC283335, SEPT9, and AKT2, and provide new replication evidence for a further 2 signals in EBF2 and NFKBIA Combining large whole-blood gene expression resources totaling 12 607 individuals, we investigated all novel and previously reported signals and identified 48 genes with evidence for involvement in blood pressure regulation that are significant in multiple resources. Three novel kidney-specific signals were also detected. These robustly implicated genes may provide new leads for therapeutic innovation.