Apixaban versus no anticoagulation after anticoagulation-associated intracerebral haemorrhage in patients with atrial fibrillation in the Netherlands (APACHE-AF):a randomised, open-label, phase 2 trial

Background In patients with atrial fibrillation who survive an anticoagulation-associated intracerebral haemorrhage, a decision must be made as to whether restarting or permanently avoiding anticoagulation is the best long-term strategy to prevent recurrent stroke and other vascular events. In APACHE-AF, we aimed to estimate the rates of non-fatal stroke or vascular death in such patients when treated with apixaban compared with when anticoagulation was avoided, to inform the design of a larger trial. Methods APACHE-AF was a prospective, randomised, open-label, phase 2 trial with masked endpoi... Mehr ...

Volltext
Verfasser: Schreuder, Floris H. B. M.
van Nieuwenhuizen, Koen M.
Hofmeijer, Jeannette
Vermeer, Sarah E.
Kerkhoff, Henk
Zock, Elles
Luijckx, Gert-Jan
Messchendorp, Gert P.
van Tuijl, Julia
Bienfait, H. Paul
Booij, Suzanne J.
van den Wijngaard, Ido R.
Remmers, Michel J. M.
Schreuder, Antonia H. C. M. L.
Dippel, Diederik W.
Staals, Julie
Brouwers, Paul J. A. M.
Wermer, Marieke J. H.
Coutinho, Jonathan M.
Kwa, Vincent I. H.
van Gelder, Isabelle C.
Schutgens, Roger E. G.
Zweedijk, Berber
Algra, Ale
van Dalen, Jan Willem
Kappelle, L. Jaap
Rinkel, Gabriel J. E.
van Der Worp, H. Bart
Klijn, Catharina J. M.
Dokumenttyp: Artikel
Erscheinungsdatum: 2021
Reihe/Periodikum: APACHE-AF Trial Investigator , Schreuder , F H B M , van Nieuwenhuizen , K M , Hofmeijer , J , Vermeer , S E , Kerkhoff , H , Zock , E , Luijckx , G-J , Messchendorp , G P , van Tuijl , J , Bienfait , H P , Booij , S J , van den Wijngaard , I R , Remmers , M J M , Schreuder , A H C M L , Dippel , D W , Staals , J , Brouwers , P J A M , Wermer , M J H , Coutinho , J M , Kwa , V I H , van Gelder , I C , Schutgens , R E G , Zweedijk , B , Algra , A , van Dalen , J W , Kappelle , L J , Rinkel , G J E , van Der Worp , H B & Klijn , C J M 2021 , ' Apixaban versus no anticoagulation after anticoagulation-associated intracerebral haemorrhage in patients with atrial fibrillation in the Netherlands (APACHE-AF) : a randomised, open-label, phase 2 trial ' , Lancet Neurology , vol. 20 , no. 11 , pp. 907-916 . https://doi.org/10.1016/S1474-4422(21)00298-2
Schlagwörter: ANTITHROMBOTIC TREATMENT / INTRACRANIAL HEMORRHAGE / SECONDARY PREVENTION / ORAL ANTICOAGULANTS / VASCULAR EVENTS / STROKE
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-26824600
Datenquelle: BASE; Originalkatalog
Powered By: BASE
Link(s) : https://hdl.handle.net/11370/1a6c2223-d0a9-4367-bdac-aba77bb879fc