Longitudinal Characterization of the Mumps-Specific HLA-A2 Restricted T-Cell Response after Mumps Virus Infection
Waning of the mumps virus (MuV)-specific humoral response after vaccination has been suggested as a cause for recent mumps outbreaks in vaccinated young adults, although it cannot explain all cases. Moreover, CD8(+) T cells may play an important role in the response against MuV; however, little is known about the characteristics and dynamics of the MuV-specific CD8(+) T-cell response after MuV infection. Here, we had the opportunity to follow the CD8(+) T-cell response to three recently identified HLA-A2*02:01-restricted MuV-specific epitopes from 1.5 to 36 months post-MuV infection in five pr... Mehr ...
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2021 |
Reihe/Periodikum: | Lanfermeijer , J , Nuehn , M M , Emmelot , M E , Poelen , M C M , van Els , C A C M , Borghans , J A M , van Baarle , D , Kaaijk , P & de Wit , J 2021 , ' Longitudinal Characterization of the Mumps-Specific HLA-A2 Restricted T-Cell Response after Mumps Virus Infection ' , Vaccines , vol. 9 , no. 12 , 1431 . https://doi.org/10.3390/vaccines9121431 ; ISSN:2076-393X |
Schlagwörter: | mumps infection / T-cell immunity / MMR vaccination / BONE-MARROW / MEMORY / DYNAMICS / IMMUNITY / VACCINE / DIFFERENTIATION / PROLIFERATION / NETHERLANDS / OUTBREAKS / MEASLES |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-26824445 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | http://hdl.handle.net/11370/0a0cecd4-1e3e-4f5a-86f0-521ff35de5f9 |