Major depressive disorder (MDD) is clinically heterogeneous with prevalence rates twice as high in women as in men. There are many possible sources of heterogeneity in MDD most of which are not measured in a sufficiently comparable way across study samples. Here, we assess genetic heterogeneity based on two fundamental measures, between-cohort and between-sex heterogeneity. First, we used genome-wide association study (GWAS) summary statistics to investigate between-cohort genetic heterogeneity using the 29 research cohorts of the Psychiatric Genomics Consortium (PGC; N cases = 16,823, N contr... Mehr ...
| Verfasser: |
Trzaskowski, Maciej
Mehta, Divya
Peyrot, Wouter J.
Hawkes, David
Davies, Daniel
Howard, David M.
Kemper, Kathryn E.
Sidorenko, Julia
Maier, Robert
Ripke, Stephan
Mattheisen, Manuel
Baune, Bernhard T.
Grabe, Hans J.
Heath, Andrew C.
Jones, Lisa
Jones, Ian
Madden, Pamela A. F.
McIntosh, Andrew M.
Breen, Gerome
Lewis, Cathryn M.
Borglum, Anders D.
Sullivan, Patrick F.
Martin, Nicholas G.
Kendler, Kenneth S.
Levinson, Douglas F.
Wray, Naomi R. |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2019 |
| Reihe/Periodikum: |
Trzaskowski , M , Mehta , D , Peyrot , W J , Hawkes , D , Davies , D , Howard , D M , Kemper , K E , Sidorenko , J , Maier , R , Ripke , S , Mattheisen , M , Baune , B T , Grabe , H J , Heath , A C , Jones , L , Jones , I , Madden , P A F , McIntosh , A M , Breen , G , Lewis , C M , Borglum , A D , Sullivan , P F , Martin , N G , Kendler , K S , Levinson , D F , Wray , N R & Major Depress Disorder Working G 2019 , ' Quantifying between-cohort and between-sex genetic heterogeneity in major depressive disorder ' , American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics , vol. 180 , no. 6 , pp. 439-447 . https://doi.org/10.1002/ajmg.b.32713 |
| Schlagwörter: |
depression
/ genetic heterogeneity
/ LD score regression
/ MDD
/ sex differences
/ GENOME-WIDE ASSOCIATION
/ SCORE REGRESSION
/ CHILDHOOD TRAUMA
/ EPIDEMIOLOGY
/ WOMEN
/ HERITABILITY
/ NETHERLANDS
/ DISEASE
/ HEALTH
/ NESDA |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-26824267 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
|
https://pure.au.dk/portal/en/publications/c9475260-fc70-4924-a8a4-196f4dc9a662 |
