Empirical Investigation of Genomic Clusters Associated with Height and the Risk of Postmenopausal Breast and Colorectal Cancer in the Netherlands Cohort Study
We empirically investigated genomic clusters associated with both height and postmenopausal breast cancer (BC) or colorectal cancer (CRC) (or both) in the Netherlands Cohort Study to unravel shared underlying mechanisms between height and these cancers. The Netherlands Cohort Study (1986-2006) includes 120,852 participants (case-cohort: nsubcohort=5000; 20.3 years follow-up). Variants in clusters on chromosomes 2, 4, 5, 6 (two clusters), 10, and 20 were genotyped using toenail DNA. Cluster-specific genetic risk scores were modelled in relation to height and postmenopausal BC and CRC risk using... Mehr ...
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2022 |
Reihe/Periodikum: | Simons , C C J M , Offermans , N S M , Stoll , M , van den Brandt , P A & Weijenberg , M P 2022 , ' Empirical Investigation of Genomic Clusters Associated with Height and the Risk of Postmenopausal Breast and Colorectal Cancer in the Netherlands Cohort Study ' , American Journal of Epidemiology , vol. 191 , no. 3 , pp. 413-429 . https://doi.org/10.1093/aje/kwab259 |
Schlagwörter: | breast cancer / breast neoplasms / cohort studies / colorectal cancer / colorectal neoplasms / genetic risk score / height / shared mechanisms / SCALE PROSPECTIVE COHORT / GENETIC ANALYSES / QUESTIONNAIRE / DIET / DNA |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-26822538 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | https://cris.maastrichtuniversity.nl/en/publications/fde08b1b-a88a-491e-ac16-4e1c8c7451be |