Purpose: The currently used prognostic models for patients with nonmetastatic clear cell renal cell carcinoma (ccRCC) are based on clinicopathologic features and might be improved by adding molecular markers. Epigenetic alterations occur frequently in ccRCC and are promising biomarkers. The aim of this study is to identify prognostic promoter methylation markers for ccRCC. Experimental Design: Weintegrated data generated by massive parallel sequencing of methyl-binding domain enriched DNA and microarray-based RNA expression profiling of 5-aza-2'-deoxycytidine-treated ccRCC cell lines to compre... Mehr ...
| Verfasser: |
van Vlodrop, Iris J. H.
Joosten, Sophie C.
De Meyer, Tim
Smits, Kim M.
Van Neste, Leander
Melotte, Veerle
Baldewijns, Marcella M. L. L.
Schouten, Leo J.
van den Brandt, Piet A.
Jeschke, Jana
Yi, Joo Mi
Schuebel, Kornel E.
Ahuja, Nita
Herman, James G.
Aarts, Maureen J.
Bosman, Fred T.
Van Criekinge, Wim
van Engeland, Manon |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2017 |
| Reihe/Periodikum: |
van Vlodrop , I J H , Joosten , S C , De Meyer , T , Smits , K M , Van Neste , L , Melotte , V , Baldewijns , M M L L , Schouten , L J , van den Brandt , P A , Jeschke , J , Yi , J M , Schuebel , K E , Ahuja , N , Herman , J G , Aarts , M J , Bosman , F T , Van Criekinge , W & van Engeland , M 2017 , ' A Four-Gene Promoter Methylation Marker Panel Consisting of GREM1, NEURL, LAD1, and NEFH Predicts Survival of Clear Cell Renal Cell Cancer Patients ' , Clinical Cancer Research , vol. 23 , no. 8 , pp. 2006-2018 . https://doi.org/10.1158/1078-0432.CCR-16-1236 |
| Schlagwörter: |
CPG ISLAND HYPERMETHYLATION
/ HIPPEL-LINDAU GENE
/ CARCINOMA
/ MUTATIONS
/ EXPRESSION
/ PROGNOSIS
/ INACTIVATION
/ NETHERLANDS
/ EVOLUTION
/ RECEPTOR |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-26822243 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
|
https://cris.maastrichtuniversity.nl/en/publications/ec3010df-9742-417a-8d50-70dfff3e40e4 |
