Harmonization of breast cancer radiotherapy treatment planning in the Netherlands

Purpose: The aim was to reach consensus in The Netherlands on which parameters should be used to evaluate breast cancer radiotherapy (RT) plans. Materials and methods: A Benchmark Case with delineated planning target volumes (PTVs) and Organs At Risk (OARs) was sent to all Dutch radiotherapy centres in combination with a questionnaire, with the request to generate RT plans prescribing 15 times 2.67 Gy for four different treatment indications according to the institutional irradiation technique. The plans and accompanying questionnaire answers were analysed using descriptive statistics. These r... Mehr ...

Verfasser: Hurkmans, Coen
Duisters, Cindy
Peters-Verhoeven, Mieke
Boersma, Liesbeth
Verhoeven, Karolien
Bijker, Nina
Crama, Koen
Nuver, Tonnis
van der Sangen, Maurice
Dokumenttyp: Artikel
Erscheinungsdatum: 2021
Reihe/Periodikum: Hurkmans , C , Duisters , C , Peters-Verhoeven , M , Boersma , L , Verhoeven , K , Bijker , N , Crama , K , Nuver , T & van der Sangen , M 2021 , ' Harmonization of breast cancer radiotherapy treatment planning in the Netherlands ' , Technical Innovations and Patient Support in Radiation Oncology , vol. 19 , pp. 26-32 . https://doi.org/10.1016/j.tipsro.2021.06.004
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-26822197
Datenquelle: BASE; Originalkatalog
Powered By: BASE
Link(s) : https://cris.maastrichtuniversity.nl/en/publications/e32dfc1e-37ae-4a22-bed2-9abb0735d07f

Purpose: The aim was to reach consensus in The Netherlands on which parameters should be used to evaluate breast cancer radiotherapy (RT) plans. Materials and methods: A Benchmark Case with delineated planning target volumes (PTVs) and Organs At Risk (OARs) was sent to all Dutch radiotherapy centres in combination with a questionnaire, with the request to generate RT plans prescribing 15 times 2.67 Gy for four different treatment indications according to the institutional irradiation technique. The plans and accompanying questionnaire answers were analysed using descriptive statistics. These results, together with a harmonisation proposal, were sent to all centres. The proposal was discussed at a meeting of the Dutch Society of Radiation Oncology breast cancer platform. Distinct parameters were accepted if consensus on them was reached. Results: 19 out of 20 Dutch departments participated in this study. PTV coverage varied considerably, with D98% between 63% and 99% for the breast and between 37% and 97% for the internal mammary nodes (IMN). Also substantial OAR dose differences were observed, with e.g. mean heart doses ranging between 1.85 Gy and 5.42 Gy in case the IMN were included in the PTV. For evaluation of the PTVs D98%, D2% and Dmean were chosen to report on, with target values of ≥ 95% (90% for the PTV_IMN), ≤ 107%, and 99-101%, respectively. For OARs, consensus was reached on the parameters to be evaluated, without target values: Dmean of the heart, Dmean and V5% of the lungs, and in case of periclavicular radiotherapy V30Gy of the thyroid gland. For patients younger than 40 years a contralateral mean breast dose of ≤ 1 Gy was agreed upon. Conclusion: A new Dutch consensus guideline for evaluation of breast cancer RT plans has been established.