The Exposome Paradigm to Understand the Environmental Origins of Mental Disorders

There is an active interest in understanding the relationship between mental disorders and modifiable and potentially preventable exposures. However, the complexity of the environment, involving many causal and noncausal pathways, makes research extremely challenging. To tackle these challenges, we have recently proposed the use of the exposome paradigm. The exposome represents the totality of exposures in a lifetime from conception onward. The framework offers a solution to handle the complexity of all "non-genetic" factors. The exposome approach has recently been adopted to construct an expo... Mehr ...