Sirtuin 1 genetic variation, energy balance and colorectal cancer risk by sex and subsite in the Netherlands Cohort Study
Sirtuin 1 (SIRT1) is an energy-sensing protein, which may affect tumorigenesis. We used SIRT1 variants as time-independent indicators of SIRT1 involvement in carcinogenesis and we studied two tagging SIRT1 variants in relation to colorectal cancer (CRC) risk. We also evaluated known energy balance-related CRC risk factors within SIRT1 genotype strata. The Netherlands Cohort Study includes 120,852 individuals and has 20.3 years follow-up (case-cohort: n(subcohort) = 5000; n(CRC cases) = 4667). At baseline, participants self-reported weight, weight at age 20, height, trouser/skirt size reflectin... Mehr ...
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2018 |
Reihe/Periodikum: | Simons , C C J M , Schouten , L J , Godschalk , R W , van Schooten , F J , van den Brandt , P A & Weijenberg , M P 2018 , ' Sirtuin 1 genetic variation, energy balance and colorectal cancer risk by sex and subsite in the Netherlands Cohort Study ' , Scientific Reports , vol. 8 , 16540 . https://doi.org/10.1038/s41598-018-34728-6 |
Schlagwörter: | SCALE PROSPECTIVE COHORT / BLOOD MONONUCLEAR-CELLS / GROWTH-FACTOR PATHWAY / PHYSICAL-ACTIVITY / BODY-SIZE / ANTHROPOMETRIC VARIABLES / FOLLOW-UP / ASSOCIATION / CARCINOMA / WOMEN |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-26821589 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | https://cris.maastrichtuniversity.nl/en/publications/6f883c54-fee7-4b26-a26d-7216bd18b023 |