Cardiovascular risk associated with interactions among polymorphisms in genes from the renin-angiotensin, bradykinin, and fibrinolytic systems
Vascular fibrinolytic balance is maintained primarily by interplay of tissue plasminogen activator (t-PA) and plasminogen activator inhibitor type 1 (PAI-1). Previous research has shown that polymorphisms in genes from the renin-angiotensin (RA), bradykinin, and fibrinolytic systems affect plasma concentrations of both t-PA and PAI-1 through a set of gene-gene interactions. In the present study, we extend this finding by exploring the effects of polymorphisms in genes from these systems on incident cardiovascular disease, explicitly examining two-way interactions in a large population-based st... Mehr ...
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| Dokumenttyp: | Artikel |
| Erscheinungsdatum: | 2010 |
| Schlagwörter: | Adult / Aged / Bradykinin / Cardiovascular Diseases / European Continental Ancestry Group / Female / Follow-Up Studies / Genetic Predisposition to Disease / Humans / Male / Middle Aged / Netherlands / Polymorphism / Genetic / Renin-Angiotensin System / Risk Factors / Tissue Plasminogen Activator |
| Sprache: | Englisch |
| Permalink: | https://search.fid-benelux.de/Record/base-26820749 |
| Datenquelle: | BASE; Originalkatalog |
| Powered By: | BASE |
| Link(s) : | https://discovery.ucl.ac.uk/id/eprint/1414411/1/journal.pone.0012757.pdf |
Vascular fibrinolytic balance is maintained primarily by interplay of tissue plasminogen activator (t-PA) and plasminogen activator inhibitor type 1 (PAI-1). Previous research has shown that polymorphisms in genes from the renin-angiotensin (RA), bradykinin, and fibrinolytic systems affect plasma concentrations of both t-PA and PAI-1 through a set of gene-gene interactions. In the present study, we extend this finding by exploring the effects of polymorphisms in genes from these systems on incident cardiovascular disease, explicitly examining two-way interactions in a large population-based study.