Background: Selective cyclooxygenase-2 inhibitors and conventional non-selective non-steroidal anti-inflammatory drugs (nsNSAIDs) have been associated with adverse cardiovascular (CV) effects. We compared the CV safety of switching to celecoxib vs. continuing nsNSAID therapy in a European setting. Method: Patients aged 60 years and over with osteoarthritis or rheumatoid arthritis, free from established CV disease and taking chronic prescribed nsNSAIDs, were randomized to switch to celecoxib or to continue their previous nsNSAID. The primary endpoint was hospitalization for non-fatal myocardial... Mehr ...
| Verfasser: |
Macdonald, Thomas M
Hawkey, Chris J
Ford, Ian
McMurray, John J V
Scheiman, James M
Hallas, Jesper
Findlay, Evelyn
Grobbee, Diederick E
Hobbs, F D Richard
Ralston, Stuart H
Reid, David M
Walters, Matthew R
Webster, John
Ruschitzka, Frank
Ritchie, Lewis D
Perez-Gutthann, Susana
Connolly, Eugene
Greenlaw, Nicola
Wilson, Adam
Wei, Li
Mackenzie, Isla S |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2017 |
| Reihe/Periodikum: |
Macdonald , T M , Hawkey , C J , Ford , I , McMurray , J J V , Scheiman , J M , Hallas , J , Findlay , E , Grobbee , D E , Hobbs , F D R , Ralston , S H , Reid , D M , Walters , M R , Webster , J , Ruschitzka , F , Ritchie , L D , Perez-Gutthann , S , Connolly , E , Greenlaw , N , Wilson , A , Wei , L & Mackenzie , I S 2017 , ' Randomized trial of switching from prescribed non-selective non-steroidal anti-inflammatory drugs to prescribed celecoxib : the Standard care vs. Celecoxib Outcome Trial (SCOT) ' , European Heart Journal , vol. 38 , no. 23 , pp. 1843-1850 . https://doi.org/10.1093/eurheartj/ehw387 |
| Schlagwörter: |
Acute Coronary Syndrome/chemically induced
/ Aged
/ Anti-Inflammatory Agents
/ Non-Steroidal/adverse effects
/ Arthritis
/ Rheumatoid/drug therapy
/ Celecoxib/adverse effects
/ Cyclooxygenase 2 Inhibitors/adverse effects
/ Denmark/epidemiology
/ Drug Substitution
/ Female
/ Hospitalization/statistics & numerical data
/ Humans
/ Male
/ Middle Aged
/ Myocardial Infarction/chemically induced
/ Netherlands/epidemiology
/ Osteoarthritis/drug therapy
/ Patient Safety
/ Peptic Ulcer Hemorrhage/chemically induced
/ Prospective Studies
/ Stroke/chemically induced
/ United Kingdom/epidemiology |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-26820325 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
|
https://portal.findresearcher.sdu.dk/da/publications/963e0807-f16f-4990-9023-5f833bfc9e74 |
