Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium

The hypoxic areas of solid cancers represent a negative prognostic factor irrespective of which treatment modality is chosen for the patient. Still, after almost 80 years of focus on the problems created by hypoxia in solid tumours, we still largely lack methods to deal efficiently with these treatment-resistant cells. The consequences of this lack may be serious for many patients: Not only is there a negative correlation between the hypoxic fraction in tumours and the outcome of radiotherapy as well as many types of chemotherapy, a correlation has been shown between the hypoxic fraction in tu... Mehr ...

Verfasser: Isabella Moser
Brad Wouters
Gerald Urban
Hilda Mujcic
Hubert Flamm
Yihai Cao
Jacques Pouysségur
Dan Cojocari
Kasper M.A. Rouschop
Heidi Lyng
Andrea Scozzafava
Silvia Pastorekova
Jan Alsner
Kjersti Flatmark
James Meehan
Agnes Görlach
Morten Busk
Afshan Ahmed
Ibtissam Marchiq
Ian Kunkler
Scott K. Parks
Nathalie M. Mazure
Kasper Toustrup
Manuel O. Landázuri
Marianne Koritzinsky
Peter Ebbesen
Johanna Chiche
Gerhard Jobst
Jens Overgaard
Andreas Weltin
Adrian L. Harris
Kaye J. Williams
Claudiu T. Supuran
Anne Hansen Ree
Philippe Lambin
Ludwig Dubois
Erik O. Pettersen
Luis del Peso
Dean C. Singleton
Francesca M. Buffa
Simon P. Langdon
Carol Ward
Maria J. Calzada
Jochen Kieninger
Syed Haider
Margaret Ashcroft
Roben G. Gieling
Dokumenttyp: Artikel
Erscheinungsdatum: 2014
Schlagwörter: Netherlands / Drug Discovery / Pharmacology / General Medicine
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-26811522
Datenquelle: BASE; Originalkatalog
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Link(s) : https://www.openaccessrepository.it/record/120385