Evaluation of interleukin-1 beta and the ratio of interleukin-1 beta to interleukin-1 receptor antagonist in gingival crevicular fluid during orthodontic canine retraction.

© 2021 by Wroclaw Medical University.Background. Orthodontic tooth movement (OTM) is a complex phenomenon mediated by cytokines, of which interleukin-1 beta (IL-1β) is potently involved in the remodeling of the periodontal ligament (PDL) and bone. Whether the pattern of IL-1β release differs at the sides of tension and compression is not yet clarified. Objectives. The aim of the present study was to evaluate the level of IL-1β and the ratio of IL-1β to interleukin-1 receptor antagonist (IL-1RA) in gingival crevicular fluid (GCF) at the tension and compression sides during orthodontic canine re... Mehr ...