Epidemiology of myasthenia gravis with anti-MuSK antibodies in the Netherlands
We studied the epidemiology of myasthenia gravis (MG) subtypes and the frequency of antibodies against Muscle Specific Kinase (MuSK) in patients with generalized MG without anti-acetylcholinereceptor antibodies who had an onset of symptoms between 1990 and 2004 in a well defined region in the Netherlands. We also studied the nationwide prevalence and incidence rate of MuSK Ab+ MG. Anti-MuSK antibodies were found in 22% of patients with generalized AChR Ab- MG. Nationwide we identified 35 patients with MuSK MG yielding a prevalence of 1.9 per million (95% CI 1.22-2.59) and an annual incidence r... Mehr ...
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| Dokumenttyp: | TEXT |
| Erscheinungsdatum: | 2006 |
| Verlag/Hrsg.: |
BMJ Publishing Group Ltd
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| Schlagwörter: | Short reports |
| Sprache: | Englisch |
| Permalink: | https://search.fid-benelux.de/Record/base-26807292 |
| Datenquelle: | BASE; Originalkatalog |
| Powered By: | BASE |
| Link(s) : | http://jnnp.bmj.com/cgi/content/short/jnnp.2006.102517v1 |
We studied the epidemiology of myasthenia gravis (MG) subtypes and the frequency of antibodies against Muscle Specific Kinase (MuSK) in patients with generalized MG without anti-acetylcholinereceptor antibodies who had an onset of symptoms between 1990 and 2004 in a well defined region in the Netherlands. We also studied the nationwide prevalence and incidence rate of MuSK Ab+ MG. Anti-MuSK antibodies were found in 22% of patients with generalized AChR Ab- MG. Nationwide we identified 35 patients with MuSK MG yielding a prevalence of 1.9 per million (95% CI 1.22-2.59) and an annual incidence rate of 0.10 per million person-years (95% CI 0.06-0.14).