Getting insurance after genetic screening on familial hypercholesterolaemia; the need to educate both insurers and the public to increase adherence to national guidelines in the Netherlands
Heterozygous familial hypercholesterolaemia (FH) is a common autosomal dominant inherited metabolic disease with a prevalence of 1 in 500 in most Western countries.<cross-ref refid="R1" type="bib">1–</cross-ref><cross-ref refid="R3" type="bib">3</cross-ref> People with FH experience an increased risk for coronary artery disease (CAD) and excess mortality especially at a young age.<cross-ref refid="R4" type="bib">4,</cross-ref><cross-ref refid="R5" type="bib">5</cross-ref> Until recently the diagnosis of FH was based on clinical signs and symptoms... Mehr ...
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| Dokumenttyp: | TEXT |
| Erscheinungsdatum: | 2002 |
| Verlag/Hrsg.: |
British Medical Journal Publishing Group
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| Schlagwörter: | Public health policy and practice |
| Sprache: | Englisch |
| Permalink: | https://search.fid-benelux.de/Record/base-26807180 |
| Datenquelle: | BASE; Originalkatalog |
| Powered By: | BASE |
| Link(s) : | http://jech.bmj.com/cgi/content/short/56/2/145 |
Heterozygous familial hypercholesterolaemia (FH) is a common autosomal dominant inherited metabolic disease with a prevalence of 1 in 500 in most Western countries.<cross-ref refid="R1" type="bib">1–</cross-ref><cross-ref refid="R3" type="bib">3</cross-ref> People with FH experience an increased risk for coronary artery disease (CAD) and excess mortality especially at a young age.<cross-ref refid="R4" type="bib">4,</cross-ref><cross-ref refid="R5" type="bib">5</cross-ref> Until recently the diagnosis of FH was based on clinical signs and symptoms alone. These included increased cholesterol concentrations, in particular of LDL-cholesterol, in combination with the presence of tendon xanthoma, corneal arcus, xanthelasmata and a history of early CAD. Frequently FH was diagnosed after a first cardiac event.