Meningococcal Disease in the Netherlands, 1958-1990: A Steady Increase in the Incidence Since 1982 Partially Caused by New Serotypes and Subtypes of Neisseria meningitidis
In order to explain a threefold increase in the incidence of meningococcal disease in the Netherlands during the 1980s, we serotyped and subtyped Neisseria meningitidis isolates recovered between 1958 and 1990 from >3,000 patients with systemic disease. No single strain could be held responsible for the increase. Apart from the newly introduced strain B:4:P1.4, which became the most prevalent phenotype in 1990 (21% of all isolates), the majority of the cases in 1990 were caused by many different strains that were already present in the Netherlands before 1980. For the period 1980–1990, a sh... Mehr ...
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Dokumenttyp: | TEXT |
Erscheinungsdatum: | 1993 |
Verlag/Hrsg.: |
Oxford University Press
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Schlagwörter: | Clinical Infectious Disease Articles |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-26806381 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | http://cid.oxfordjournals.org/cgi/content/short/16/2/237 |
In order to explain a threefold increase in the incidence of meningococcal disease in the Netherlands during the 1980s, we serotyped and subtyped Neisseria meningitidis isolates recovered between 1958 and 1990 from >3,000 patients with systemic disease. No single strain could be held responsible for the increase. Apart from the newly introduced strain B:4:P1.4, which became the most prevalent phenotype in 1990 (21% of all isolates), the majority of the cases in 1990 were caused by many different strains that were already present in the Netherlands before 1980. For the period 1980–1990, a shift in the age distribution of patients with meningococcal disease from younger to older age categories was found, particularly with regard to cases due to meningococci of serogroup B; this shift is explained by the changing distribution of serotypes and subtypes within serogroup B. A polyvalent group B, class 1 outer-membrane-protein vaccine of a stable composition could theoretically have prevented ∼80% of all group B meningococcal infections in the Netherlands during the past 30 years.