Fat and K-ras mutations in sporadic colorectal cancer in The Netherlands Cohort Study

Background/Aim: Associations between dietary intake of various fats and specific K-ras mutations in colorectal cancer (CRC) were investigated within the framework of the Netherlands Cohort Study on diet and cancer (NLCS). Methods: After 7.3 years of follow-up and with exclusion of the first 2.3 years, 448 colon and 160 rectal cancer patients and 3048 subcohort members (55-69 years at baseline) were available for data-analyses. Mutation analysis of the K-ras gene was performed on all archival colon and rectal adenocarcinoma specimens. Case-cohort analyses were used to compute adjusted incidence... Mehr ...