Adverse drug reactions of systemic antihistamines in children in the Netherlands

Background Antihistamines are used for the treatment of allergic rhinitis, allergic conjunctivitis, chronic spontaneous urticaria and atopic eczema. Objective To study the reports of adverse drug reactions (ADRs) in children using antihistamines to provide prescribers with an overview of the possible toxicity. Design We studied ADRs in children reported to the Netherlands Pharmacovigilance Centre Lareb in the years 1991–2014, assessed the Naranjo score and, when possible, computed the reporting OR. Results Serious ADRs included one death (malignant neuroleptic syndrome), cardiac arrhythmia (on... Mehr ...