Outcome of BRCA1- compared with BRCA2-associated ovarian cancer: a nationwide study in the Netherlands

Background Recent studies suggested an improved overall survival (OS) for BRCA2 - versus BRCA1 -associated epithelial ovarian cancer (EOC), whereas the impact of chemotherapy is not yet clear. In a nationwide cohort, we examined the results of primary treatment, progression-free survival (PFS), treatment-free interval (TFI), and OS of BRCA1 versus BRCA2 EOC patients. Methods Two hundred and forty-five BRCA1 - and 99 BRCA2 -associated EOC patients were identified through all Dutch university hospitals. Analyses were carried out with the Pearson's Chi-square test, Kaplan–Meier, and Cox regressio... Mehr ...