Symptomatic brain metastases from small-cell carcinoma of the urinary bladder: The Netherlands Cancer Institute experience and literature review

Background: The incidence of symptomatic brain metastases in small-cell carcinoma of the urinary bladder (SCBC) is unknown. This precludes advice about prophylactic cranial irradiation (PCI). Patients and methods: The medical records of all patients with SCBC seen at The Netherlands Cancer Institute from 1993 to 2009 ( n = 51) were reviewed. Limited disease (LD) was defined as any pT, cN 0–1 , and cM 0 . Patients with LD were offered bladder-preserving treatment involving combined chemoradiotherapy. Patients with extensive disease (ED) were treated with palliative chemotherapy. PCI was not app... Mehr ...