Population- and Type-Specific Clustering of Multiple HPV Types Across Diverse Risk Populations in the Netherlands

In view of possible type replacement upon introduction of human papillomavirus (HPV) vaccination, we aimed to explore patterns of type-specific clustering across populations with various background infection risks. A total of 3,874 women from 3 cross-sectional studies in the Netherlands (in 2007–2009) provided vaginal self-samples, which were tested for 25 HPV genotypes by a sensitive molecular assay (SPF 10 line probe assay, DDL Diagnostic Laboratory, Voorburg, the Netherlands). The number of concurrent HPV infections per woman was studied by Poisson regression. Associations between HPV types... Mehr ...