Urinary Excretions of High Molecular Weight {beta}-Thromboglobulin and Albumin Are independently Associated with Coronary Heart Disease in Women, a Nested Case-Control Study of Middle-aged Women in the Diagnostisch Onderzoek Mammacarcinoom (DOM) Cohort, Utrecht, Netherlands

Increased plasma levels of β-thromboglobulin, a platelet activation marker, are observed in coronary artery disease. Urinary albumin excretion, a marker of endothelial cell perturbation, is related to cardiovascular disease in diabetes. To test the value of these markers in predicting forthcoming coronary disease, the relations between urinary excretions of high molecular weight β-thromboglobulin (HMW-βTG) and albumin and subsequent coronary disease in a cohort of 15,484 middle-aged women were investigated in a nested case-control study. Baseline questionnaire data and urine samples were avail... Mehr ...