Polymorphisms in the mTOR-PI3K-Akt pathway, energy balance-related exposures and colorectal cancer risk in the Netherlands Cohort Study
Abstract Background The mTOR-PI3K-Akt pathway influences cell metabolism and (malignant) cell growth. We generated sex-specific polygenic risk scores capturing natural variation in 7 out of 10 top-ranked genes in this pathway. We studied the scores directly and in interaction with energy balance-related factors (body mass index (BMI), trouser/skirt size, height, physical activity, and early life energy restriction) in relation to colorectal cancer (CRC) risk in the Netherlands Cohort Study (NLCS) (n=120,852). The NLCS has a case-cohort design and 20.3 years of follow-up. Participants completed... Mehr ...
Verfasser: | |
---|---|
Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2022 |
Reihe/Periodikum: | BioData Mining, Vol 15, Iss 1, Pp 1-20 (2022) |
Verlag/Hrsg.: |
BMC
|
Schlagwörter: | Body size / Cohort studies / Colorectal neoplasms / Mechanistic target of rapamycin / Polymorphisms / Computer applications to medicine. Medical informatics / R858-859.7 / Analysis / QA299.6-433 |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-26800454 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | https://doi.org/10.1186/s13040-021-00286-3 |