Tic symptom dimensions and their heritabilities in Tourette's syndrome.
IntroductionGilles de la Tourette's syndrome (TS) is both genotypically and phenotypically heterogeneous. Gene-finding strategies have had limited success, possibly because of symptom heterogeneity.ObjectiveThis study aimed at specifically investigating heritabilities of tic symptom factors in a relatively large sample of TS patients and family members.Participants and methodsLifetime tic symptom data were collected in 494 diagnosed individuals in two cohorts of TS patients from the USA (n=273) and the Netherlands (n=221), and in 351 Dutch family members. Item-level factor analysis, using a te... Mehr ...
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| Dokumenttyp: | Artikel |
| Erscheinungsdatum: | 2015 |
| Reihe/Periodikum: | Psychiatric genetics, vol 25, iss 3 |
| Verlag/Hrsg.: |
eScholarship
University of California |
| Schlagwörter: | Humans / Tourette Syndrome / Tics / Obsessive-Compulsive Disorder / Psychiatric Status Rating Scales / Adolescent / Adult / Middle Aged / Costa Rica / United States / Netherlands / Female / Male / Young Adult / Clinical Research / Neurodegenerative / Genetics / Brain Disorders / factor analysis / heritability / heterogeneity / tic symptom factors / Tourette's syndrome / Clinical Sciences / Neurosciences / Psychiatry |
| Sprache: | unknown |
| Permalink: | https://search.fid-benelux.de/Record/base-26791869 |
| Datenquelle: | BASE; Originalkatalog |
| Powered By: | BASE |
| Link(s) : | https://escholarship.org/uc/item/50s091kz |
