APOE-related risk of mild cognitive impairment and dementia for prevention trials: An analysis of four cohorts
BackgroundWith the onset of prevention trials for individuals at high risk for Alzheimer disease, there is increasing need for accurate risk prediction to inform study design and enrollment, but available risk estimates are limited. We developed risk estimates for the incidence of mild cognitive impairment (MCI) or dementia among cognitively unimpaired individuals by APOE-e4 dose for the genetic disclosure process of the Alzheimer's Prevention Initiative Generation Study, a prevention trial in cognitively unimpaired APOE-e4/e4 homozygote individuals.Methods and findingsWe included cognitively... Mehr ...
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2017 |
Reihe/Periodikum: | PLOS Medicine, vol 14, iss 3 |
Verlag/Hrsg.: |
eScholarship
University of California |
Schlagwörter: | Health Services and Systems / Health Sciences / Neurosciences / Brain Disorders / Prevention / Alzheimer's Disease / Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) / Acquired Cognitive Impairment / Neurodegenerative / Aging / Clinical Research / Dementia / Neurological / Aged / Apolipoproteins E / Cognitive Dysfunction / Cohort Studies / Female / Gene Frequency / Genotype / Humans / Male / Middle Aged / Netherlands / Risk Factors / United States / Medical and Health Sciences / General & Internal Medicine / Biomedical and clinical sciences |
Sprache: | unknown |
Permalink: | https://search.fid-benelux.de/Record/base-26791860 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | https://escholarship.org/uc/item/3dk6r5w2 |