Heritability and genomics of gene expression in peripheral blood
We assessed gene expression profiles in 2,752 twins, using a classic twin design to quantify expression heritability and quantitative trait loci (eQTLs) in peripheral blood. The most highly heritable genes (∼777) were grouped into distinct expression clusters, enriched in gene-poor regions, associated with specific gene function or ontology classes, and strongly associated with disease designation. The design enabled a comparison of twin-based heritability to estimates based on dizygotic identity-by-descent sharing and distant genetic relatedness. Consideration of sampling variation suggests t... Mehr ...
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2014 |
Reihe/Periodikum: | Nature Genetics, vol 46, iss 5 |
Verlag/Hrsg.: |
eScholarship
University of California |
Schlagwörter: | Biotechnology / Human Genome / Genetics / Blood / Gene Expression Profiling / Gene Expression Regulation / Genotype / Humans / Inheritance Patterns / Likelihood Functions / Netherlands / Polymorphism / Single Nucleotide / Quantitative Trait Loci / Biological Sciences / Medical and Health Sciences / Developmental Biology |
Sprache: | unknown |
Permalink: | https://search.fid-benelux.de/Record/base-26791833 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | https://escholarship.org/uc/item/1700z0hv |