White cell counts in relation to mortality in a general population of cohort study in the Netherlands: a mediating effect or not?

BACKGROUND:White cell count (WCC) is a clinical marker of inflammation. Data are limited regarding the association of total and differential WCC with risk of mortality, and its role related with smoking and body mass index (BMI). METHODS:A total of 14 433 participants (4150 men; 10 283 women; average age 47.3±11.8 years) from the Dutch European Prospective Investigation into Cancer and Nutrition-Netherlands cohort were included. The associations between prediagnostic total WCC and its subtypes and risk of all-cause, cancer and cardiovascular disease (CVD) mortality were assessed. The role of W... Mehr ...

Volltext
Verfasser: Abete, Itziar
Lu, Yunxia
Lassale, Camille
Verschuren, Monique
van der Schouw, Yvonne
Bueno-de-Mesquita, Bas
Dokumenttyp: Artikel
Erscheinungsdatum: 2019
Reihe/Periodikum: BMJ Open, vol 9, iss 10
Verlag/Hrsg.: eScholarship
University of California
Schlagwörter: Epidemiology / Biomedical and Clinical Sciences / Public Health / Health Sciences / Prevention / Cancer / Clinical Trials and Supportive Activities / Obesity / Clinical Research / Nutrition / Cardiovascular / Good Health and Well Being / Adult / Aged / Body Mass Index / Case-Control Studies / Female / Humans / Leukocyte Count / Longitudinal Studies / Male / Middle Aged / Mortality / Netherlands / Proportional Hazards Models / Prospective Studies / Risk Factors / Smoking / Surveys and Questionnaires / Young Adult / mediation / white cell count / Clinical Sciences / Public Health and Health Services / Other Medical and Health Sciences / Psychology
Sprache: unknown
Permalink: https://search.fid-benelux.de/Record/base-26791812
Datenquelle: BASE; Originalkatalog
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Link(s) : https://escholarship.org/uc/item/01n309h5